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A major UK clinical study is evaluating non-invasive transcutaneous vagus nerve stimulation combined with rehabilitation therapy for arm recovery after stroke. The TRICEPS trial — TRanscutaneous lImb reCovEry Post-Stroke — is an ongoing UK clinical study investigating whether transcutaneous vagus nerve stimulation can support arm recovery after stroke when combined with rehabilitation therapy. Led by Sheffield Teaching Hospitals NHS Foundation Trust and managed by the Clinical Trials Research Unit at the University of Sheffield, the UK-based study focuses on people with arm weakness after stroke. The study is currently recruiting across multiple centres in England and Wales. TRICEPS is not the first investigation of vagus nerve stimulation in stroke rehabilitation. Rather, it builds on a growing body of clinical research exploring how vagus nerve stimulation may enhance motor recovery when paired with rehabilitation exercises. The University of Sheffield describes TRICEPS as a double-blinded, randomised, controlled, three-arm, two-stage adaptive trial designed to evaluate whether rehabilitation effects for arm recovery after stroke can be enhanced with transcutaneous vagus nerve stimulation. In the TRICEPS protocol, stimulation is delivered non-invasively through the ear using a small earpiece. This approach does not require surgery or anaesthesia and is paired with self-delivered rehabilitation therapy. Participants receive either tVNS or sham tVNS alongside rehabilitation, while remaining blinded to which treatment they receive. The study reflects the growing clinical interest in non-invasive neuromodulation for neurorehabilitation. By combining tVNS with rehabilitation exercises, researchers aim to better understand how vagus nerve stimulation may contribute to motor recovery after stroke. As one of the major ongoing studies in this field, TRICEPS reflects the growing clinical interest in non-invasive vagus nerve stimulation as a complementary approach in post-stroke rehabilitation.

Inspiring Insights from Prof. Dr. Halil Özcan on Vagus Nerve Stimulation🌟 It's been two months since our enlightening conversation with Prof. Dr. Halil Özcan, Head of the Department of Psychiatry at Atatürk University in Erzurum, Turkey. Prof. Özcan has been at the forefront of numerous successful treatments with our tVNS ® Vagus Nerve Stimulation Device since 2021. During our discussion, Prof. Özcan shared invaluable experiences and insights into vagal nerve stimulation and its diverse applications across various indications. He recounted remarkable stories of recovery, notably highlighting exceptional improvements in coma patients after receiving treatment. With over two decades of research in clinical studies worldwide, Prof. Özcan's pioneering work has paved the way for the use of vagus nerve stimulation in treating conditions such as depression, anxiety disorders, and sleep problems, yielding positive outcomes at Neuromodulation centers. His positive experiences with chronic migraine and tinnitus patients offer hope for millions facing similar challenges, showcasing the potential of vagal nerve stimulation to revolutionize healthcare as a low side-effect option for various conditions. We extend our heartfelt gratitude to Prof. Dr. Halil Özcan and Atatürk University for their invaluable contributions to advancing science and restoring countless patients to a new lease on life. We eagerly anticipate future collaborations and groundbreaking studies. For more insights, visit our website and YouTube channel, and feel free to reach out for treatment protocols and clinical details.

Dr. Barış Ekici, Assistant Professor and Pediatric Neurologist, shares his insights and expertise on transcutaneous vagus nerve stimulation (tVNS) treatment. Vagus nerve stimulation is a technique that stimulates the vagus nerve. It has been approved as a treatment for epilepsy since 1997 and for treatment-resistant depression since 2005. Vagus nerve stimulation creates a pulse that travels from the brainstem to the higher centers in the brain, carrying an electrical signal from the brainstem to the amygdala, hippocampus, and prefrontal cortex. Initially, devices implanted via surgery on the vagus nerve were used. The human ear contains a vast network of nerve stimulations. In particular, branches of the vagus nerve intensively travel to the brain in the concha, the hollow part of the ear. Using this device, we send some repeated stimulations at microampere levels and microsecond intervals to the ear, transmitting a signal from the brainstem to the brain. Vagus nerve stimulation affects the chemicals in the brain and activates the GABAergic system, which we know functions poorly in children with autism. Studies have shown that after vagus nerve stimulation, levels of GABAergic metabolites increase, while glutamate decreases in the cerebrospinal fluid. It also stimulates and regulates serotonergic and noradrenergic systems. Additionally, it calms the brain and reduces neuroinflammation. With vagus nerve stimulation, we expect children with autism to be calmer, more focused, with improved sleep quality, reduced obsessions, and increased speech ability. Our patients' feedback aligns with these expectations. Thanks to modern devices, we now have the opportunity to apply this method to children through the ear, and we have started to see positive effects after one month of stimulation. The good aspect is that, after planning the stimulation according to the child's electroencephalogram (EEG), the family can apply this method at home on their own. We do not observe many side effects. Mild side effects such as ear redness and occasional headaches have been reported. So far, our patients are satisfied with vagus nerve stimulation. Overall, we receive feedback from parents that their child has become calmer, more focused, and has increased speech ability. When activities increase in children with autism, you lose the ability to perform. Therefore, I believe that vagus nerve stimulation, which works from the brainstem to the brain and helps the child find their balance in a calming way, is very suitable for children with autism.

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Excessive drug use in children can cause developmental delay. tVNS provides long-term positive results by reducing the need for drug use. tVNS is safe for children and approved for pediatric use. tVNS provides benefits in mental development and motor development. Use of tVNS® in Children tVNS is safe for children and MDR CE approved for pediatric use Epilepsy, Autism, Prader Willy Syndrom are the approved indications Young children should use the device under parental supervision. Excessive drug use in children can cause developmental delay. tVNS provides long-term positive results by reducing the need for drug use. Reducing drug use helps prevent the side effects of anti-epileptic drugs Improves energy, concentration, and mood Children who are using the therapy in the long term can experience cognitive and motor improvement