tVNS® is a transcutaneous vagus nerve stimulation device for the treatment of symptoms of sympathovagal imbalance. It is approved for epilepsy, autism, insomnia, tinnitus, cognitive impairment, depression and migraine. Changing the World Changing the Lives Elevate your health journey and discover a medication-free, low side effect and non-invasive therapy option for the treatment of neurological diseases. Time to meet a better version of your life. I'm a Patient I’m a Physician I’m a Researcher Become a Distributor Learn more about tVNS Health GmbH tVNS Health GmbH offers worldwide sales and solution services for tVNS® devices for the selected regions , ensuring widespread access to revolutionary neuromodulation treatments across the globe. To play, press and hold the enter key. To stop, release the enter key. tVNS® Devices are Trusted by Leading Institutions Worldwide Why We Lead in Vagus Nerve Stimulation? For over 20 years , our commitment to innovation has positioned us at the forefront of non-invasive vagus nerve stimulation. Our unmatched research and development efforts are backed by solid clinical trials, ensuring our devices are not only effective but also safe and reliable. As an approved Class IIa medical device under the EU-MDR , we offer scientifically validated solutions in a market crowded with unverified alternatives. Since introducing the Cerbomed Nemos® device, we’ve led the market in non-invasive vagus nerve technology. Our pioneering approach and sustained innovation keep us ahead, with our devices being preferred by healthcare professionals and researchers worldwide due to unmatched safety, reliability and precision. Developed and manufactured in Germany, our devices meet the highest quality standards, reflecting our dedication to excellence and the well-being of our patients. Discover tVNS Patient Discover tVNS Research tVNS® In the Media To play, press and hold the enter key. To stop, release the enter key. tVNS® Healing Stories News from tVNS® tVNS Coma Symposium, Warsaw, Poland "tVNS therapy in Comatose Patients" has been a focus research area in recent years in collaboration with esteemed scientists from... Transcutaneous Vagus Nerve Stimulation (tVNS) in Autism. Pediatric neurology specialist Associate Professor Dr. Barış Ekici shares his insights and experiences with transcutaneous vagus nerve stimu Information on tVNS from PD Dr Ranni von Wrede and Dr Pukrowski from Klinik für Epileptologie, UKB Bonn PD. Dr. Ranni von Wrede and Dr. Pukrowski, leading epileptologists from the University of Bonn, discuss the concept of Transcutaneous... A real life epilepsy story of Elena : tVNS in West and Aicardi Syndrome Discover the inspiring journey of Elena, a young girl with Aicardi syndrome and drug-resistant epilepsy, and the positive impact of tVNS... A real life epilepsy story of Oguzhan: tVNS in Dravet Syndrome and Resistant Epilepsy Zeliha Korkmaz, the mother of 7-year-old Oğuzhan, who battles resistant epilepsy and was diagnosed with Dravet syndrome at 4.5 months... Inspiring Insights and 2 coma recovery cases from Prof. Dr. Halil Özcan on Vagus Nerve Stimulation Professor Dr. Halil Özcan, shares insights on his 2 years tVNS experience and 2 coma recovery testimonials Contact Our Global tVNS Experts Worldwide Name Select inquiry: Choose an option Email : Country Please enter you message here Code Phone (optional) I have read and agree to the Privacy Policy Send Thanks for submitting!

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Pioneering Neuromodulation Research with tVNS® Discover why tVNS® is the preferred device for research on transcutaneous vagus nerve stimulation.With its precise cymba concha stimulation and wireless parameter flexibility, tVNS offers cutting-edge technology and unparalleled flexibility to explore new therapeutic protocols.Approved under the EU-MDR and backed by CB reports, our tVNS device ensures adherence to the highest standards of safety and efficacy in medical research. tVNS® R for Research Transcutaneous Vagus Nerve Stimulation Device for Research Full Wireless Parameter Programmability Patient App for Data Collection Support for Clinical Trials Triggered tVNS® Legacy and Hook Electrode Sham Stimulation tVNS® Devices are Trusted by Leading Institutions Worldwide To play, press and hold the enter key. To stop, release the enter key. Why We Lead in Vagus Nerve Stimulation? For over 20 years, our commitment to innovation has positioned us at the forefront of non-invasive vagus nerve stimulation. Our unmatched research and development efforts are backed by solid clinical trials, ensuring our devices are not only effective but also safe and reliable. As an approved Class IIa medical device under the EU-MDR, we offer scientifically validated solutions in a market crowded with unverified alternatives. Since introducing the Cerbomed Nemos® device, we’ve led the market in non-invasive vagus nerve technology. Our pioneering approach and sustained innovation keep us ahead, with our devices being preferred by healthcare professionals and researchers worldwide due to unmatched safety, reliability and precision. Developed and manufactured in Germany, our devices meet the highest quality standards, reflecting our dedication to excellence and the well-being of our patients. Learn More About tVNS Health GmbH Why Choose our tVNS® Devices for Research? Our tVNS® device is the only non-invasive vagus nerve stimulator that is approved as a Class IIa medical device under the European Medical Device Regulation (EU-MDR). tVNS® sets itself apart with its non-invasive, clinically validated approach, offering a safer and more comfortable alternative to invasive methods. Uniquely targeting the cymba concha for 100% innervation of the auricular branch of the vagus nerve (ABVN) with our patented electrode, tVNS® ensures maximum efficacy compared to other devices that only achieve partial innervation. Introducing the tVNS® Triggerbox Launching December 1, 2024, the tVNS® Triggerbox advances neuromodulation research by providing a cable-bound system that minimizes latencies and enhances protocol reproducibility. This key advancement ensures precise, reliable experimental setups for cutting-edge studies. EU-MDR Cla ss IIa Approved Medical Device Our tVNS® E device is the only non-invasive vagus nerve stimulation (VNS) device that is approved as a medical device under the EU-MDR. The supporting comprehensive CB reports not only highlight our device’s safety and efficacy but also facilitate smoother approval processes for your research protocols by ethics committees. EU-MDR Cla ss IIa Cymba Concha Stimulation Benefit from our device’s electrode design, targeting the cymba concha, a method preferred by researchers for its 100% innervation of the auricular branch of the vagus nerve (ABVN). This targeted approach is designed to maximize therapeutic outcomes by engaging the vagus nerve more effectively than other non-invasive methods. EU-MDR Cla ss IIa Wireless Connectivity and Programmability Leverage the power of wireless technology for seamless operation and data management. The tVNS® Research app enables remote programming of stimulation parameters, providing the flexibility needed to adapt to the evolving needs of complex research protocols without interrupting the participant’s experience. EU-MDR Cla ss IIa Made in Germany Trust in the quality and reliability of a device that’s proudly designed and manufactured in Germany. Our commitment to excellence guarantees that every tVNS® device meets the highest standards of performance, durability, and safety, making it the ideal choice for institutions demanding the best in research equipment. EU-MDR Cla ss IIa Titanium-Iridium Electrode Our tVNS® device features titanium-iridium electrodes, most often used in implants and known for their biocompatibility, offering optimal stimulation with minimal irritation. This superior choice sets us apart from stainless steel alternatives, ensuring a more comfortable and effective treatment experience. EU-MDR Cla ss IIa GDPR-Compliant Data Processing With a commitment to privacy and security, our tVNS® system ensures that all data collected through the app is processed in strict adherence to the General Data Protection Regulation (GDPR). Researchers can collect, store, and analyze sensitive data with confidence, knowing that participant privacy is protected. EU-MDR Cla ss IIa Global Network of Trusted Institutions Join an esteemed community of researchers from leading universities and hospitals around the world who have chosen tVNS® for their studies in the global effort to advance neurological research and patient care. EU-MDR Cla ss IIa 20+ Years of Experience With over 20 years of dedicated research and development, we proudly developed the world's first approved non-invasive vagus nerve stimulator, the Cerbomed Nemos® device. Our deep-rooted expertise and pioneering spirit have established us as leaders in the field, committed to delivering groundbreaking and effective solutions for our patients. tVNS® for Research: An Overview Welcome to the frontier of vagus nerve stimulation research. Our tVNS® R device is designed for flexibility and precision, offering full wireless programmability for comprehensive clinical studies. With the tVNS® Research and tVNS® Patient apps, adjustment of stimulation parameters, data collection and patient feedback are seamlessly integrated, enhancing the scope and accuracy of your research. We are committed to facilitating your clinical trials and provide support for studies, including a comprehensive CB safety report for ethics approvals and access to a global network of experts. Explore the potential of tVNS® R to forge new paths in neurological research and patient care. Full Wireless Parameter Programmability and Triggered tVNS® With the tVNS® Research app, you have the capability to wirelessly adjust a comprehensive range of parameters including frequency, pulse width, current intensity, and stimulation intervals. In addition, we offer a separate PC-based tVNS® manager software. This software enables reaction to outside trigger signals (e.g. ECG R-wave trigger generated by an external ECG system, transferred to a PC). Thus, closed loop tVNS® or triggered tVNS® can be realized in a scientific setup. Precision in Research with the tVNS® Triggerbox The new tVNS® Triggerbox, launching December 1, 2024, marks a significant advancement in the field of tVNS® research. Designed in response to feedback from scientific communities, this device addresses the crucial need for more stable and reproducible stimulation protocols in tVNS®. By replacing Bluetooth connections with a cable-bound system, the tVNS® Triggerbox significantly reduces latencies and fluctuations, enabling precise synchronization with external trigger signals. This innovation not only enhances the reliability of experimental setups but also simplifies the integration with existing research frameworks, promising to push the boundaries of tVNS® research further. Research and Patient App Your tVNS® R device gives you access to two apps: the tVNS® Research and tVNS® Patient app. All technical parameters can easily be reprogrammed and wirelessly transmitted with the tVNS® Research app, allowing the researcher to try completely new stimulation protocols. In addition, you can collect and store technical and patient data. The tVNS® Patient app automatically stores all technical data (stimulation parameters, time and duration of the stimulation etc.) and offers a questionnaire for patient feedback. tVNS® Patient is fully compliant with the General Data Protection Regulation (GDPR), ensuring that patient data is handled with the utmost care and confidentiality. Customization and Support for Trials We offer an individual adaptation of all components of the device for certain studies, e.g by changing the questionnaire in order to allow better feedback from the patient, or through the implementation of special stimulation parameters or technical ideas. The tVNS® R device is defined as a device for investigational use. We can provide a CB report that proves the safety according to all medical device standards, in order to assist you with ethics approvals. So far, it has been accepted by all ethics committees. In addition, we offer an international expert network and can direct any questions to experienced people around the world. Legacy and Hook Electrode We offer two different types of electrode designs with our tVNS® devices: The Hook Electrode (left) allows for better fixation and usability during active tasks. It also allows patients to wear earphones. The Legacy Electrode (right) can be used if the patient has small ears or a special ear shape. The integrated slider allows for better adaption to the ear. Sham and fMRI Electrode Options The well-known sham-stimulation option at the earlobe is possible with our Legacy Electrode. Upon request, we also provide more sophisticated sham-stimulation options, as well as fMRI-compatible electrodes. Support for Clinical Trials We offer an individual adaptation of all parts for certain studies, e.g by changing the questionnaire in order to allow better feedback from the patient, or through the implementation of special stimulation parameters or technical ideas. The tVNS® R device is defined as a device for investigational use. We can provide a CB report that proves the safety according to all medical device standards, in order to assist you with ethics approvals. So far, it has been accepted by all ethics committees. In addition, we offer an international expert network and can direct any questions to experienced people around the world. Book a Personal Consultation with our Research Experts Contact our tVNS® Research Team to learn more about tVNS® and receive personalized information and support, such as CB Reports and Instructions for Use (IFU). 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tVNS non-surgical, drug-free treatment with low side effects. The most up-to-date health information on the causes, symptoms, and treatment options of depression. Gain more freedom and self-determination. Treat depression with tVNS®. Depression Depression is a mood disorder that negatively affects the way one thinks and feels, interfering with one’s daily activities. It is characterized by a p ersistent feeling of sadness and hopelessness along with a loss of interest in activities that were once enjoyed. Treatment Options for Depression Medication There are different types of medications that can be used to treat depression including serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), Monoamine Oxidase Inhibitors (MAOIs), tricyclic and tetracyclic antidepressants, and many others. The doctor or pharmacist will inform patients about the possible mild or severe side effects of these drugs upon prescription, which will be followed by close monitoring for the first few weeks after starting the medication. Psychotherapy Psychotherapy is a general term for continuing treatment of depression which entails talking to a mental health professional about one’s condition and related issues. Psychotherapy is also known as talk therapy or psychological therapy. Different types of psychotherapy, such as cognitive behavioral therapy or trauma therapy, can be effective for depression depending on the patient. Hospital Treatment Some cases of severe depression requir e in-patient hospital stays. This may be necessary when the individual is unable to properly care for themselves and is in danger of harming themselves or others. Psychiatric treatment in a hospital can help an individual stay calm and safe until their mood improves. Partial hospital or day treatment programs may also help some individuals. Electroconvulsive therapy (ECT) In EC T, electrical currents are passed through the brain to impact the function and effect of neurotransmitters in your brain to relieve depression. ECT is usually used for people who don’t get better with medications, can’t take antidepressants for health reasons, or are at high risk of suicide. Transcranial magnetic stimulation (TMS) TMS may be an option for those who haven’t responded to antidepressants. During TMS, a treatment coil, placed against your scalp, sends brief magnetic pulses to stimulate nerve cells in your brain that are involved in mood regulation and depression. Transcutaneous Vagus Nerve Stimulation (tVNS) The tVNS® auricular vagus stimulation device is a treatment option that provides vagus nerve stimulation through the ear. The increase in parasympathetic activity from the stimulation provides relaxation and a calming effect. The increased release of serotonin provides a positive change in mood and the increased sleep quality leads to an improvement in the overall quality of life. Significant decreases in Hamilton Rating Scale for Depression, increase in Resting State Functional Connectivity and decrease in Beck Depression Inventory can be observed. tVNS® has very low side effects compared to drug options. tVNS® has helped many patients suffering from depression to reduce or completely eliminate their symptoms and lead a more self-determined and free life. Contact Us

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Distributor Services tVNS Health GmbH offers: Access to tVNS Neuromodulation Academy: for training of the new distributors on tVNS devices and transcutaneous vagal neuromodulation Support on local marketing, sales training and go-to-market strategy Support on onboarding activities . Become a tVNS Distributor

tVNS is a medical treatment that involves delivering electrical impulses to the vagus nerve with the aid of a electrode. It is used in the treatment of indications such as Epilepsy, Coma, Migraine, Depression, Cognitive Disorder, Crohn's Disease, Insomnia, Autism, Tinnitus, Stroke. What is Vagus Nerve? The vagus nerve is the longest cranial nerve in the body. It comes from the Latin word, vagus, for “wandering.” That’s because it wanders throughout your body, with wide distribution connecting the brainstem to the body. Only mammals have this nerve. The vagus nerve serves as the body's superhighway, carrying information between the brain and the internal organs and controlling the body's response in times of rest and relaxation. It helps the immune system and inflammation response to disease. It has four main functions: sensory, special sensory, motor and parasympathetic. The vagus nerve also manages fears and sends information from the gut to the brain, which is linked to dealing with stress, anxiety, and fear–hence the saying, ‘gut feeling'. Historical Development of Vagus Nerve Stimulation Epilepsy has existed in human history with the first record found in a Babylonian text written 4000 years ago, and humanity has sought a cure for this disease for centuries. With the emergence of neurology in the 19th century, the mechanism between the nervous system and epilepsy was tried to be solved and the first vagus nerve stimulation was tried by a New York neurologist in the early 1880s. Over the next 100 years, the effects of vagus nerve stimulation were first investigated in animal experiments, then in humans, and in 1988, an invasive vagus nerve stimulator was surgically implanted into the cervical branch. At the beginning of the 2000s, scientists started working on alternative ways to stimulate the vagus nerve non-invasively, to eliminate the need for surgery and minimize the side effects. First generation transcutaneous vagus nerve stimulation device, Nemos, was approved in 2010 for the treatment of epilepsy and depression, and Vitos in 2012 for the treatment of pain and migraine, as the first medically approved non-invasive vagus nerve stimulation treatment in the world. Our 2nd generation device tVNS has been launched in 2021, and tVNS patient devices have become the first MDR CE-certified transcutaneous vagus nerve stimulation devices in the world, in 2023. Vagus Nerve Stimulation Effect Overview Regulation of neurotransmitter release Increase in parasympathetic activity Increase in brain neuroplasticity Reducing inflammation Increasing the secretion of serotonin and increasing the mood What Are the Effects of Vagus Nerve Stimulation? Stimulation of the vagus triggers regulatory mechanisms in the nervous, immune, autonomic, endocrine, cardiorespiratory, and gastrointestinal systems. Clinical studies on the vagus nerve have shown that the activity in this nerve is closely related to epilepsy, depression, migraine, headache, inflammatory bowel disease, Alzheimer's, arthritis and many other common disorders by activating the parasympathetic nervous system in the brain and increasing the secretion of neurotransmitters in special regions of the brain. Vagus nerve stimulation therapies are approved by FDA in the USA and CE in Europe for use in treatments such as epilepsy, mood improvement, pain relief, sleep improvement, memory enhancement and anxiety reduction. Research continues on the effects of neuroplasticity as well as its cardiac and inflammatory properties.

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