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Clinical Studies

Vagus nerve stimulation (VNS) has become a therapeutic option for patients with resistant epilepsy and depression. The field of tVNS is quickly progressing due to its non-invasive nature, presenting a promising alternative to the side effects associated with invasive VNS. Notably, tVNS stands out for its accessibility, affordability, and easiness of application compared to traditional VNS methods. However, the non-invasive stimulation of the outer ear brings forth new queries regarding optimal stimulation sites, stimulus parameters, and the physiological pathways of transcutaneous auricular VNS. Over the past two decades, both basic and clinical research have made significant strides, unraveling these complexities, enhancing our comprehension of tVNS pathways and physiological effects.
The exponential growth in publications over the last years underscores the expanding knowledge base. As we delve deeper, therapeutic applications and achievable objectives of tVNS beyond epilepsy and depression treatment are continually broadening, promising new horizons in the field.
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Redgrave 2018: Safety and Tolerability of tVNS
Wrede Case Study 2019 : Sustained seizure freedom with transcutaneous vagal nerve stimulation in drug-resistant epilepsy caused by subcortical band heterotopias

Yakunina 2016: Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional MRI
Bauer 2015: Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial

Straube 2015: Treatment of chronic migraine with Transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial
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tVNS JOURNAL

The "tVNS Special Issue", which includes 17 studies on our tVNS devices, has been published in the "Journal Autonomic Neuroscience" by Elsevier,  the official journal of the International Society for Autonomic Neuroscience.



 
autonomic neuroscience
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