Drug-free non-surgical tvns vagal nerve stimulation in the treatment of tinnitus. The most up-to-date health information on tinnitus causes, symptoms, treatment options Tinnitus Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Contact us

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tVNS, non-surgical treatment option for epilepsy. The most up-to-date health information about epilepsy causes, symptoms, treatment options Less seizures - more from life. Treat drug-resistant epilepsy wit h tVNS® Epilepsy An epileptic seizure is a clinical condition that occurs when the normal activity of the brain is disrupted by the temporary abnormal electrical acti vity in the nerve cells. Epilepsy is the recurrence of epileptic seizures and is considered a chronic disease. While anticonvulsants are commonly prescribed, many epileptic patients are resist ant to drug therapy. Treatment Options for Drug Resistant Epilepsy Epilepsy Surgery There are two methods of neurosurgery: removal of the brain region that causes seizures and surgical cutting of the neural pathways that cause seizures to spread. However, since these methods are only suitable for focal epilepsies, only a small proportion of epilepsy patients are suitable for this invasive procedure. In deep brain stimulation, electrodes are implanted in the brain. These electrodes are attached to a battery operated stimulator that is usually placed under the patient’s collarbone. Epileptic activity can be specifically affected at the baseline through current stimuli. Deep Brain Stimulation Invasive Vagus Nerve Stimulation In some patients, a treatment called “vagus nerve stimulation”, also known as brain pacemaker surgery, can be applied. With a surgical intervention, a battery is placed under the chest and an electrode wire is placed in the vagus nerve in the neck. With the help of the electrode, the vagus nerve is stimulated at regular intervals, which may reduce seizures. Transcutaneous Vagus Nerve Stimulation The tVNS® auricular vagus nerve stimulation device is a treatment option that provides vagus nerve stimulation through the ear with a smartphone-sized device and a special headset without any surgical intervention. From there, as with invasive vagus nerve stimulation, higher centers of the brain are activated, triggering an anticonvulsant effect. How does tVNS® treat epilepsy? In transcutaneous vagus nerve stimulation, mild electrical impulses are given to the cymba concha region in the outer auricle through a special ear electrode. These stimuli activate the vagus nerve, which passes directly under the skin in this region (auricular branch of the vagus nerve). The nerve first transmits these impuleses to the Nucleus Tractus Solitarius in the brain stem and are transmitted to many different regions of the diencephalon (midbrain) and cerebrum. These stimuli are also transmitted to the Norepinephrine (Noradrenaline) center, the Locus Coeruleus, and Serotonin center, the Dorsal Raphe nucleus. These transmitters affect one’s clarity, energy, and confidence. These 2 centers send these neurotransmitters to the entire brain, specifically to the parts that control thinking and feeling. more serotonin and norepinephrine are then sent to the Prefrontal Cortex and are inhibited in the Hippocampus and Anterior Thalamus regions, which reduces anxiety and panic. This mechanism causes the frequency or severity of seizures to be reduced or stopped entirely. tVNS has helped hundreds of patients suffering from epilepsy to reduce or completely eliminate their seizures and lead a more self-determined life, without the need for surgery. “It’s wonderful that with tVNS® I have found a therapy option that makes me feel better without needing surgery.” Katja S. from Munich

tVNS non-surgical, drug-free treatment with low side effects. The most up-to-date health information on the causes, symptoms, and treatment options of depression. Gain more freedom and self-determination. Treat depression with tVNS®. Depression Depression is a mood disorder that negatively affects the way one thinks and feels, interfering with one’s daily activities. It is characterized by a p ersistent feeling of sadness and hopelessness along with a loss of interest in activities that were once enjoyed. Treatment Options for Depression Medication There are different types of medications that can be used to treat depression including serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), Monoamine Oxidase Inhibitors (MAOIs), tricyclic and tetracyclic antidepressants, and many others. The doctor or pharmacist will inform patients about the possible mild or severe side effects of these drugs upon prescription, which will be followed by close monitoring for the first few weeks after starting the medication. Psychotherapy Psychotherapy is a general term for continuing treatment of depression which entails talking to a mental health professional about one’s condition and related issues. Psychotherapy is also known as talk therapy or psychological therapy. Different types of psychotherapy, such as cognitive behavioral therapy or trauma therapy, can be effective for depression depending on the patient. Hospital Treatment Some cases of severe depression requir e in-patient hospital stays. This may be necessary when the individual is unable to properly care for themselves and is in danger of harming themselves or others. Psychiatric treatment in a hospital can help an individual stay calm and safe until their mood improves. Partial hospital or day treatment programs may also help some individuals. Electroconvulsive therapy (ECT) In EC T, electrical currents are passed through the brain to impact the function and effect of neurotransmitters in your brain to relieve depression. ECT is usually used for people who don’t get better with medications, can’t take antidepressants for health reasons, or are at high risk of suicide. Transcranial magnetic stimulation (TMS) TMS may be an option for those who haven’t responded to antidepressants. During TMS, a treatment coil, placed against your scalp, sends brief magnetic pulses to stimulate nerve cells in your brain that are involved in mood regulation and depression. Transcutaneous Vagus Nerve Stimulation (tVNS) The tVNS® auricular vagus stimulation device is a treatment option that provides vagus nerve stimulation through the ear. The increase in parasympathetic activity from the stimulation provides relaxation and a calming effect. The increased release of serotonin provides a positive change in mood and the increased sleep quality leads to an improvement in the overall quality of life. Significant decreases in Hamilton Rating Scale for Depression, increase in Resting State Functional Connectivity and decrease in Beck Depression Inventory can be observed. tVNS® has very low side effects compared to drug options. tVNS® has helped many patients suffering from depression to reduce or completely eliminate their symptoms and lead a more self-determined and free life. Contact Us

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Contains information about tVNS clinical research devices tVNS® R for Research Discover a Revolutionary Journey with Innovative tVNS® Research Device Meet the cutting-edge realm of vagus nerve stimulation research, where innovation meets precision in our state-of-the-art tVNS® R device. Crafted for flexibility and accuracy, it boasts complete wireless programmability, making it the perfect companion for in-depth clinical studies. Experience seamless control with the tVNS® Research and tVNS® Patient apps, integrating stimulation parameter adjustments, data collection, and patient feedback to elevate the depth and precision of your research. Our commitment extends beyond technology; we're here to streamline your clinical trials, providing robust support for your studies, including a thorough CB safety report for swift ethics approvals and access to a global network of experts. Uncover the limitless potential of tVNS® R as it pioneers revolutionary paths in neurological research and transforms the landscape of patient care. Your journey to groundbreaking discoveries starts here. tVNS® R for Research Transcutaneous Vagus Nerve Stimulation Device for Research Full Wireless Parameter Programmability Patient App for Data Collection Support for Clinical Trials Triggered tVNS® Legacy and Hook Electrode Sham Stimulation Research and Patient App Your tVNS® R device gives you access to two apps: the tVNS® Research and tVNS® Patient app. All technical parameters can easily be reprogrammed and wirelessly transmitted with the tVNS® Research app, allowing the researcher to try completely new stimulation protocols. In addition, you can collect and store technical and patient data. The tVNS® Patient app automatically stores all technical data (stimulation parameters, time and duration of the stimulation etc.) and offers a questionnaire for patient feedback. Support for Clinical Trials We offer an individual adaptation of all parts for certain studies, e.g by changing the questionnaire in order to allow better feedback from the patient, or through the implementation of special stimulation parameters or technical ideas. The tVNS® R device is defined as a device for investigational use. We can provide a CB report that proves the safety according to all medical device standards, in order to assist you with ethics approvals. So far, it has been accepted by all ethics committees. In addition, we offer an international expert network and can direct any questions to experienced people around the world. Triggered tVNS® We offer a separate PC-based tVNS® manager software. This software enables reaction to outside trigger signals (e.g. ECG R-wave trigger generated by an external ECG system, transferred to a PC). Thus, closed loop tVNS® or triggered tVNS® can be realized in a scientific setup. Legacy and Hook Electrode We offer two different types of electrode designs with our tVNS® devices: The Hook Electrode (left) comes standard with all new tVNS® devices. It offers bet ter fixation and usability during daily activities. The Legacy Electrode (right) can be used if the patient has small ears or a special ear shape. The integrated slider allows for better adaption to the ear. Sham Stimulation The well known sham stimulation at the ear lobe is still possible. Upon request, we support studies by providing other more sophisticated sham stimulation options.

During the last 20 years, basic and clinical research has unraveled many of these questions and augmented our understanding of tVNS pathways and physiologic effects. The number of publications increased exponentially within the last three years and continues to grow rapidly. Many questions have been addressed and therapeutic indications beyond the treatment of drug-resistant epilepsy and depression are steadily expanding and continue to be explored. Clinical Studies Vagus nerve stimulation (VNS) has become a therapeutic option for patients with resistant epilepsy and depression. The field of tVNS is quickly progressing due to its non-invasive nature, presenting a promising alternative to the side effects associated with invasive VNS. Notably, tVNS stands out for its accessibility, affordability, and easiness of application compared to traditional VNS methods. However, the non-invasive stimulation of the outer ear brings forth new queries regarding optimal stimulation sites, stimulus parameters, and the physiological pathways of transcutaneous auricular VNS. Over the past two decades, both basic and clinical research have made significant strides, unraveling these complexities, enhancing our comprehension of tVNS pathways and physiological effects. The exponential growth in publications over the last years underscores the expanding knowledge base. As we delve deeper, therapeutic applications and achievable objectives of tVNS beyond epilepsy and depression treatment are continually broadening, promising new horizons in the field. Redgrave 2018: Safety and Tolerability of tVNS Wrede Case Study 2019 : Sustained seizure freedom with transcutaneous vagal nerve stimulation in drug-resistant epilepsy caused by subcortical band heterotopias Yakunina 2016: Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional MRI Ellrich 2019: Transcutaneous Auricular Vagus Nerve Stimulation Study Bauer 2015: Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial Straube 2015: Treatment of chronic migraine with Transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial tVNS JOURNAL The "tVNS Special Issue", which includes 17 studies on our tVNS devices, has been published in the "Journal Autonomic Neuroscience" by Elsevier, the official journal of the International Society for Autonomic Neuroscience. Journal For more please contact us info@tvns.health

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TVNS treatment in Crohn's disease. The most up-to-date health information on crohn's disease causes, symptoms, treatment options Crohn's Disease Groundbreaking Technologies for Life What is Crohn's Disease ? Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. Crohn's Disease Symptoms Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Insomnia Tanı Yöntemleri Crohn's Disease Causes Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease. Crohn's Disease Diagnostic Methods Blood analysis Stool analysis Stomach, small and large intestine films Colonoscopy and endoscopy CT and MRI images Crohn's disease can occur at any age, but it usually occurs when the disease is young. Most people who develop Crohn's disease are diagnosed before they reach the age of about 30. You are at higher risk for the disease if you have a first-degree relative with the disease, such as a parent, sibling, or child. About 1 in 5 people with Crohn's disease have a family member with the disease. Facts About Crohn's Disease Treatment Options for Crohn's Disease Medication Steroid drugs: These are drugs to reduce inflammation in the digestive system. Drugs for the immune system: These are drugs used to control the immune system. More information Surgical treatment Most Crohn's Disease patients may need surgical treatment. Removing the problematic parts of the digestive system and reconnecting them to healthy parts is the aim of surgical treatment. More information Crohn's Disease Diet In general, the patient is given a high-energy, abundant protein, low-fiber, low-fat diet rich in vitamins and minerals. For some patients, consumption of milk and dairy products is prohibited. More information Transcutaneous Vagus Nerve Stimulation (tVNS) tVNS ® reduces inflammation in the intestine, allowing the intestine to do its job more healthily. More information Contact us

tVNS non-surgical tvns treatment for cognitive impairment, dementia and alzheimer's. The most up-to-date health information on cognitive impairment causes, symptoms, and treatment options Cognitive Impairment Groundbreaking Technologies for Life What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are comm on in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. Types of Cognitive Disorder Demantia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to c hronic cerebrovascular disease, alcoholic dementia, depr essive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. There are dementias that start with memory impairment such as Alzheimer's disease, as well as behavioral disorders, skill disorders, depression, There are also dementias that start with the symptoms of parkinson's disease and language disorders. It is a progressive disease. Alzhemeir It is the most common type of dementia is a neurological disease that causes the destruction of brain cells. The disease, which causes a decrease in thought, memory and behavioral functions, occurs after a long time with advancing age. It may take years for the disease to reach advanced stages. Because it is a progressive disease, Alzheimer's patients experience problems such as inability to perform their daily tasks, forgetfulness and serious confusion. People with memory loss or other possible Alzheimer's symptoms may have trouble recognizing that they have a problem. Treatment Options for Cognitive Disorder There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Contact us

tVNS Health Gmbh is a medical technology sales company based in Grünwald, Germany, that has been responsible for the global distribution, services, and operations management of tVNS devices. tVNS® in Italia: tVNS Health GmbH | E. M. S. s. r. l tVNS Health GmbH è un’azienda tedesca specializzata nella vendita di tecnologie mediche, responsabile della distribuzione, dei servizi e delle vendite globali dei dispositivi tVNS® per la stimolazione non invasiva del nervo vago auricolare in Europa dell’Est, Scandinavia, Asia, Africa, Sud America e Italia . Il progettista e produttore dei dispositivi tVNS® è tVNS Technologies GmbH , con sede a Erlangen, in Germania. Dal 2010, anno in cui il dispositivo Cerbomed Nemos® ha ottenuto l'approvazione medica come primo dispositivo per la stimolazione non invasiva del nervo vago auricolare, Cerbomed Nemos® e il nuovo tVNS® sono stati utilizzati in migliaia di trattamenti in tutto il mondo, migliorando significativamente la qualità della vita dei pazienti. E.M.S. s.r.l. è un’azienda commerciale fondata a Bologna nel 1994 e certificata ISO 9001. Specializzata nella commercializzazione di apparecchiature elettromedicali e dei relativi sistemi software, l’azienda si è affermata come partner affidabile nel settore della tecnologia medica. Grazie a una profonda competenza in neuropsicologia, neurologia, neuroriabilitazione e neurochirurgia, E.M.S. offre soluzioni innovative, esclusive e di alta qualità. Con una solida rete commerciale e una struttura organizzativa avanzata, l’azienda serve ospedali e centri di ricerca neurofisiologica con prodotti che superano gli standard qualitativi del mercato. In Italia, E.M.S. s.r.l. è il distributore ufficiale di tVNS Health GmbH e tVNS Technologies GmbH , offrendo servizi di vendita e assistenza per i dispositivi tVNS® e garantendo un ampio accesso ai trattamenti di neuromodulazione. tVNS Health GmbH Vendite e servizi globali: Südliche Münchner Str. 62, 82031 Grünwald, Germany info@tvns.health www.tvns.health E. M. S. s. r. l Distributore in Italia: Via di Saliceto 81, 40128 Bologna Italy www.emsmedical.net Tel. +39-051-398925 Contattaci