TVNS treatment in Crohn's disease. The most up-to-date health information on crohn's disease causes, symptoms, treatment options Crohn's Disease Groundbreaking Technologies for Life What is Crohn's Disease ? Crohn's disease is a type of inflammatory bowel disease that causes inflammation of the gastrointestinal tract from the mouth to the anus. This inflammation can be attached to one or more parts of the digestive system, but it is usually seen in the ileum, which is the last part of the small intestine, and in the beginning of the large intestine. Crohn's disease can cause inflammation in your digestive tract, leading to abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition. Growth-development retardation in children may be signs of Crohn's disease. Extra-intestinal diseases are also observed in a quarter of Crohn's patients. These mostly occur in the skin, joints, eyes, liver and biliary tract, kidney and urinary tract, vascular heart and lungs. Crohn's Disease Symptoms Diarrhea Abdominal pains Intestinal blockages Fever Fatigue Loss of appetite and weight loss Still feeling full after using the toilet Frequent toileting is one of the early symptoms of Crohn's disease. Insomnia Tanı Yöntemleri Crohn's Disease Causes Immune system: It is possible for a virus or bacteria to trigger Crohn's disease; however, scientists have yet to identify such a trigger. When your immune system tries to fight off the invading microorganism, an abnormal immune response can cause the immune system to attack cells in the digestive tract as well. Heredity: Crohn's disease is more common in people with a family history of the same disease, so genes may play a role in the occurrence of the disease. Crohn's Disease Diagnostic Methods Blood analysis Stool analysis Stomach, small and large intestine films Colonoscopy and endoscopy CT and MRI images Crohn's disease can occur at any age, but it usually occurs when the disease is young. Most people who develop Crohn's disease are diagnosed before they reach the age of about 30. You are at higher risk for the disease if you have a first-degree relative with the disease, such as a parent, sibling, or child. About 1 in 5 people with Crohn's disease have a family member with the disease. Facts About Crohn's Disease Treatment Options for Crohn's Disease Medication Steroid drugs: These are drugs to reduce inflammation in the digestive system. Drugs for the immune system: These are drugs used to control the immune system. More information Surgical treatment Most Crohn's Disease patients may need surgical treatment. Removing the problematic parts of the digestive system and reconnecting them to healthy parts is the aim of surgical treatment. More information Crohn's Disease Diet In general, the patient is given a high-energy, abundant protein, low-fiber, low-fat diet rich in vitamins and minerals. For some patients, consumption of milk and dairy products is prohibited. More information Transcutaneous Vagus Nerve Stimulation (tVNS) tVNS ® reduces inflammation in the intestine, allowing the intestine to do its job more healthily. More information Contact us

tVNS non-surgical, drug-free treatment with low side effects. The most up-to-date health information on the causes, symptoms, and treatment options of depression. Gain more freedom and self-determination. Treat depression with tVNS®. Depression Depression is a mood disorder that negatively affects the way one thinks and feels, interfering with one’s daily activities. It is characterized by a p ersistent feeling of sadness and hopelessness along with a loss of interest in activities that were once enjoyed. Treatment Options for Depression Medication There are different types of medications that can be used to treat depression including serotonin-norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), Monoamine Oxidase Inhibitors (MAOIs), tricyclic and tetracyclic antidepressants, and many others. The doctor or pharmacist will inform patients about the possible mild or severe side effects of these drugs upon prescription, which will be followed by close monitoring for the first few weeks after starting the medication. Psychotherapy Psychotherapy is a general term for continuing treatment of depression which entails talking to a mental health professional about one’s condition and related issues. Psychotherapy is also known as talk therapy or psychological therapy. Different types of psychotherapy, such as cognitive behavioral therapy or trauma therapy, can be effective for depression depending on the patient. Hospital Treatment Some cases of severe depression requir e in-patient hospital stays. This may be necessary when the individual is unable to properly care for themselves and is in danger of harming themselves or others. Psychiatric treatment in a hospital can help an individual stay calm and safe until their mood improves. Partial hospital or day treatment programs may also help some individuals. Electroconvulsive therapy (ECT) In EC T, electrical currents are passed through the brain to impact the function and effect of neurotransmitters in your brain to relieve depression. ECT is usually used for people who don’t get better with medications, can’t take antidepressants for health reasons, or are at high risk of suicide. Transcranial magnetic stimulation (TMS) TMS may be an option for those who haven’t responded to antidepressants. During TMS, a treatment coil, placed against your scalp, sends brief magnetic pulses to stimulate nerve cells in your brain that are involved in mood regulation and depression. Transcutaneous Vagus Nerve Stimulation (tVNS) The tVNS® auricular vagus stimulation device is a treatment option that provides vagus nerve stimulation through the ear. The increase in parasympathetic activity from the stimulation provides relaxation and a calming effect. The increased release of serotonin provides a positive change in mood and the increased sleep quality leads to an improvement in the overall quality of life. Significant decreases in Hamilton Rating Scale for Depression, increase in Resting State Functional Connectivity and decrease in Beck Depression Inventory can be observed. tVNS® has very low side effects compared to drug options. tVNS® has helped many patients suffering from depression to reduce or completely eliminate their symptoms and lead a more self-determined and free life. Contact Us

tVNS treatment in sleep disorders. The most up-to-date health information on sleep disorders causes, symptoms, treatment options INSOMNIA (SLEEP DISORDER) What is Insomnia? Insomnia is a common sleep disorder that makes it difficult to fall asleep and stay asleep, or to wake up too early and not be able to go back to sleep. People with insomnia feel tired when they wake up. Insomnia can reduce not only energy level and mood, but also health, work performance and quality of life. It is the disease of not being able to sleep in sufficient time and restful sleep. During the existence of the disease, symptoms such as irregularity in sleeping hours, sudden night awakenings, difficulty falling asleep after waking up, and waking up very early in the morning are observed. The existence of a regular sleep time and long naps does not mean that we will wake up the next day rested and ready to work. In studies on sleep and sleeping problems, it is said that an adult individual should sleep 7-8 hours every night. However, the resting process, which differs from person to person, can change the person's sleep duration. Types of Insomnia Acute insomnia: It refers to the short-term appearance of insomnia. Acute insomnia usually occurs after a stressful day or on days when mental tension is high. Our body clock has a hard time showing when it's time to rest on such difficult days. This irregularity, which usually lasts for 1 to 2 days, continues unti l we feel better. There are signs of acute insomnia that can last up to 4 weeks. Chronic Insomnia: A sleep disorder that lasts for 1 month or more is called chronic insomnia. A large proportion of 10-15% of adults suffer from chronic insomnia. Compared to acute insomnia, chronic insomnia requires medical attention. The main cause of this type of disorder is usually the presence of major depression. Hypersomnia: characterized by excessive sleepiness and excessive daytime sleep requirements. It is less common than insomnia. Narcolepsy : Includes excessive daytime sleepiness and abnormal findings in daily REM sleep for at least 3 months. Narcolepsy is an abnormality in the sleep mechanism, especially in the REM mechanism. Treatment Options for Insomnia Sleep Techniques Airflow in and out of the lungs during breathing Blood oxygen levels. Body position. Brain waves (EEG) More information CPAP Titration (Mask Therapy) Some cases of severe depression require a hospital stay. This may be necessary in situations where the individual is unable to take care of themselves properly and is in danger of harming themselves or someone else. More information Polysomnography Sleep test. It is a process that is done by recording with the help of devices all night long to determine the quality of sleep and to find the cause of the sleep disorder. More information Transcutaneous Vagus Nerve Stimulation (tVNS) Communication between the gut and the brain is provided by the vagus nerve. More information WE DESIGN THE MEDICAL TECHNOLOGIES OF THE FUTURE Contact us

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tVNS is a medical treatment that involves delivering electrical impulses to the vagus nerve with the aid of a electrode. It is used in the treatment of indications such as Epilepsy, Coma, Migraine, Depression, Cognitive Disorder, Crohn's Disease, Insomnia, Autism, Tinnitus, Stroke. What is Vagus Nerve? The vagus nerve is the longest cranial nerve in the body. It comes from the Latin word, vagus, for “wandering.” That’s because it wanders throughout your body, with wide distribution connecting the brainstem to the body. Only mammals have this nerve. The vagus nerve serves as the body's superhighway, carrying information between the brain and the internal organs and controlling the body's response in times of rest and relaxation. It helps the immune system and inflammation response to disease. It has four main functions: sensory, special sensory, motor and parasympathetic. The vagus nerve also manages fears and sends information from the gut to the brain, which is linked to dealing with stress, anxiety, and fear–hence the saying, ‘gut feeling'. Historical Development of Vagus Nerve Stimulation Epilepsy has existed in human history with the first record found in a Babylonian text written 4000 years ago, and humanity has sought a cure for this disease for centuries. With the emergence of neurology in the 19th century, the mechanism between the nervous system and epilepsy was tried to be solved and the first vagus nerve stimulation was tried by a New York neurologist in the early 1880s. Over the next 100 years, the effects of vagus nerve stimulation were first investigated in animal experiments, then in humans, and in 1988, an invasive vagus nerve stimulator was surgically implanted into the cervical branch. At the beginning of the 2000s, scientists started working on alternative ways to stimulate the vagus nerve non-invasively, to eliminate the need for surgery and minimize the side effects. First generation transcutaneous vagus nerve stimulation device, Nemos, was approved in 2010 for the treatment of epilepsy and depression, and Vitos in 2012 for the treatment of pain and migraine, as the first medically approved non-invasive vagus nerve stimulation treatment in the world. Our 2nd generation device tVNS has been launched in 2021, and tVNS patient devices have become the first MDR CE-certified transcutaneous vagus nerve stimulation devices in the world, in 2023. Vagus Nerve Stimulation Effect Overview Regulation of neurotransmitter release Increase in parasympathetic activity Increase in brain neuroplasticity Reducing inflammation Increasing the secretion of serotonin and increasing the mood What Are the Effects of Vagus Nerve Stimulation? Stimulation of the vagus triggers regulatory mechanisms in the nervous, immune, autonomic, endocrine, cardiorespiratory, and gastrointestinal systems. Clinical studies on the vagus nerve have shown that the activity in this nerve is closely related to epilepsy, depression, migraine, headache, inflammatory bowel disease, Alzheimer's, arthritis and many other common disorders by activating the parasympathetic nervous system in the brain and increasing the secretion of neurotransmitters in special regions of the brain. Vagus nerve stimulation therapies are approved by FDA in the USA and CE in Europe for use in treatments such as epilepsy, mood improvement, pain relief, sleep improvement, memory enhancement and anxiety reduction. Research continues on the effects of neuroplasticity as well as its cardiac and inflammatory properties.

tVNS Health Services and Solutions: At tVNS Health GmbH, we offer distinctive solutions and services tailored for the tVNS device ecosystem. Our expertise includes training healthcare professionals and organizations in the essentials of the therapy and device operation. Additionally, we extend online training and personalized therapy tracking services to patients and their families. This ensures the proper utilization of the devices, maximizing the benefits derived from this innovative technology. With a passion for solving unmet needs, we bring together technology, neuromodulation expertise and leading opinion leaders to create never-before-seen solutions. tVNS® Academy Training Our tVNS Training Services are designed to support patients as they begin their journey with transcutaneous vagus nerve stimulation (tVNS). We offer personalized, 1-on-1 training sessions tailored to individual needs, providing patients with expert guidance every step of the way. Access a range of online training materials and connect with a dedicated therapy consultant fluent in multiple languages for continuous support and assistance, ensuring a smooth and effective therapy experience. Contact our team tVNS® Care Services Our online tracking services aim patients achieve optimal results by accurately monitoring therapy, verifying the device utilization and compliance to the therapy plan. In addition, we offer access to a network of physicians experienced in transcutaneous vagus nerve neuromodulation therapy, providing professional consultation and guidance tailored to each patient's needs. Contact our team tVNS® Rental Services For doctors and patients interested in experiencing the benefits of our device before making a purchase, we offer customized rental service for different requirements and indications. Check the availability of this service in your country to start your trial today. Contact our team Request for Information

Non-surgical, drug-free, low side-effect treatment for tVNS migraine. The most up-to-date health information about migraine causes, symptoms, treatment options Migraines Migraines manifest as a neurological disorder characterized by an intense, pulsating headache, frequently concentrated on one side of the head. Unique features setting migraines apart from other headaches include nausea, vomiting, and heightened sensitivity to sound and light. The intensity of the pain often hinders the performance of daily tasks, resulting in limitations. Notably, migraine attacks stand as a primary contributor to disability and work-related absence in developed nations Less migraines - more from life. Treatment Options for Migraines Acupuncture Treatment One of the most commonly used treatment methods for migraine treatment in western countries is acupuncture. Acupuncture has the ability to increase the release of endorphins in the body which act as powerful pain relievers. At the same time, acupuncture also activates calming chemicals in the body. Botulinum Toxin Treatment Another treatment method in chronic migraine patients is botulinum toxin treatment, which has been applied since 2010. The frequency and severity of pain can be reduced by applying it to patients who use too many painkillers and are unresponsive to other treatments. This treatment is generally well tolerated and there are no serious side effects. Dry Needle Therapy Dry needle therapy is a drug-free, scientific treatment method based on the stimulation of the trigger points in the muscles in different parts of the body using special needles of different sizes. Migraine Surgery Migraine surgery is the intervention of the nerve branches located in the forehead, temples, neck and nape root of the migraine-related regions of the brain, and to the vessels and muscles around these nerve branches. With surgery, these anatomical structures may be permanently damaged, nerve endings may be damaged and ‘neuropathic pains’ may occur. Anti-CGRP Injection CGRP plays a key role in dilating or widening blood vessels. The injection works to block the sites in and around the brain in place of CRGP or binds directly to CGRP and prevents it from being effective. The effects are not yet known. Medications that lower CRGP may cause side effects that affect your blood pressure and heart. Transcutaneous Vagus Nerve Stimulation The tVNS® auricular vagus stimulation device is a treatment option that provides vagus nerve stimulation through the ear with a smartphone-sized device and a special headset without any surgical intervention. How does tVNS® treat migraines? The focus of migraine therapy with tVNS® is the activation of the parasympathetic part of the autonomic nervous system. This part of the nervous system is always active when we are relaxing or resting and is responsible for cell regeneration and metabolic processes. The stimulation of the parasympathetic nervous system triggers the necessary regeneration processes of inflammatory areas and acts as a recovery accelerator. Neurostimulation with tVNS® is used both as a migraine prophylaxis and during an acute attack. While drugs are taken orally and thus develop their effect systematically, they are often accompanied by numerous undesirable side effects. Therapy with tVNS® , on the other hand, has the advantage that it activates the parasympathetic system directly by stimulating the vagus nerve on the ear and has very few side effects. tVNS® has helped hundreds of patients suffering from migraines to reduce or completely eliminate migraines and lead a more self-determined life. “The idea of treating migraine without medication appealed to me immediately. And now, a year and a half after the first application, I have a completely new quality of life.” M. Dohring from Berlin Contact Us

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Drug-free non-surgical tvns vagal nerve stimulation in the treatment of tinnitus. The most up-to-date health information on tinnitus causes, symptoms, treatment options Tinnitus Tinnitus and Vagus Nerve Stimulation Tinnitus can also be defined as the patient's perception of a sound without an acoustic stimulus. This sound can have different tones, features and characters. The sound most often heard as ringing is sometimes described as humming, bells, wind or whistling, machinery noise, rustling, pulsing sounds. Tinnitus is considered as a symptom rather than a disease and is treated as such. It is the most common symptom of the auditory system. These complaints may be severe enough to cause mental problems or severely impair the quality of life, and in some people, tinnitus may come and go within a few minutes. Clinical studies have shown that vagus nerve stimulation provides an increase in parasympathetic activity, calms the patient, reduces sleep disorders due to tinnitus, and decreases THI (Tinnitus Handicap Inventoy). For more detailed information, please contact tVNS Turkey. Contact us

tVNS non-surgical tvns treatment for cognitive impairment, dementia and alzheimer's. The most up-to-date health information on cognitive impairment causes, symptoms, and treatment options Cognitive Impairment Groundbreaking Technologies for Life What is Cognitive Impairment? The shrinkage caused by the loss of cells in the brain causes various functional disorders. These dysfunctions may manifest as dementia, Alzheimer, and mild cognitive impairment, which are comm on in people ives. People with cognitive impairment are at high risk for Alzheimer and dementia. When adequate precautions are taken, cognitive impairment may regress, and it is possible for these people to lead a normal life. Types of Cognitive Disorder Demantia It is the inadequacies experienced in language, skills and orientation, especially forgetfulness. Dementia is a family that includes many different types. There are Alzheimer's, dementia due to c hronic cerebrovascular disease, alcoholic dementia, depr essive dementia, dementia due to infections, etc. Dementia occurs as a result of general deterioration of the upper level functions of the cerebral cortex, especially over 75 years of age, with advancing age. There are dementias that start with memory impairment such as Alzheimer's disease, as well as behavioral disorders, skill disorders, depression, There are also dementias that start with the symptoms of parkinson's disease and language disorders. It is a progressive disease. Alzhemeir It is the most common type of dementia is a neurological disease that causes the destruction of brain cells. The disease, which causes a decrease in thought, memory and behavioral functions, occurs after a long time with advancing age. It may take years for the disease to reach advanced stages. Because it is a progressive disease, Alzheimer's patients experience problems such as inability to perform their daily tasks, forgetfulness and serious confusion. People with memory loss or other possible Alzheimer's symptoms may have trouble recognizing that they have a problem. Treatment Options for Cognitive Disorder There is no drug therapy approved to treat cognitive impairment. Medicines used to treat symptoms of Alzheimer's disease have been tried. Some studies have found that using these drugs for cognitive impairment is helpful, while others have concluded that there is no benefit. It has been noted that the use of other drugs, including NSAIDs, Ginkgo, Biloba and vitamin E, does not provide a great benefit. tVNS Effect Mechanism There are many clinical studies in recent years that cognitive disorders are caused by inflammation in the brain. Although the basic efficacy mechanism of tVNS has not been fully resolved, our new generation devices in 2021 became the first neuromodulation therapy approved for cognitive impairment in the world, due to both its benefits in the treatment of inflammation and the increase in neuroplasticity. Contact us

Explore our current partnerships and discover opportunities to join us in distributing our tVNS® devices. Shaping the Future of Non-Invasive Healing. Together. Explore our current partnerships and discover opportunities to join us in distributing our tVNS® devices. Distributor Services tVNS Health GmbH offers: Access to tVNS ® Neuromodulation Academy: for training of the new distributors on tVNS devices and transcutaneous vagal neuromodulation Support on local marketing, sales training and go-to-market strategy Support on onboarding activities Become a tVNS Distributor tVNS Health Gmbh is the distribution and service gateway to a game-changer neuromodulation product - tVNS® auricular vagus nerve stimulation device - from tVNS Technologies GmbH in selected countries in Europe, and all regions in Asia, Africa, Oceania, and South America.

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