Why tVNS® ?

No Surgery

Non-surgical vagus nerve stimulation with full patient control and no invasive- risks

Few Side Effects

tVNS® has very few side effects compared to drugs and invasive treatments, and easily tolarable.

Pediatric Flexibility

It is safe for the children, enabling a low side effect drug-free therapy

More Flexibility

Rechargeable battery allows flexible parameters and treatment protocols.

Customized Therapy

Customizsable based on indication and needs, so can provide a unique solution for every patient.

Easy to Use

Easy to use, as small as a smartphone and can be easily integrated into everyday life.

Innovative App

With the tVNS® Patient App you can track your treatment, share results and get consultation

Remote Training

tVNS® allows remote delivery and training without any need for travel

What is tVNS®?

Non-invasive vagus nerve stimulation for the treatment of neurological diseases

Navigating the world of medical treatments can be overwhelming, especially when faced with persistent and challenging health issues. Whether you’ve been tirelessly seeking effective solutions, or if traditional drug therapies have been unsuccessful, there is another option: tVNS®.

The vagus nerve, central to our body’s nervous system, plays a critical role in maintaining homeostasis. tVNS®, or Transcutaneous Vagus Nerve Stimulation, harnesses the therapeutic potential of this nerve through targeted stimulation of its auricular branch, accessible within the ear.

This innovative approach utilizes gentle electrical impulses to modulate the vagus nerve’s activity, encouraging a state of balance across the body’s systems. The result? A reduction in the symptoms of neurological diseases associated with sympathovagal imbalance, achieved through a method that avoids the invasiveness of surgery and the side effects associated with medication. Approved as a Class IIa medical device under the European Medical Device Regulation (MDR), tVNS® sets a new standard in the treatment of neurological conditions, offering a blend of efficacy, safety, and simplicity.

tVNS® is indicated to treat the following conditions:

Epilepsy
Autism
Anxiety
Migraine
Parkinson's

Depression
Cognitive Impairment
Prader-Willi Syndrome
Sleep Disorders

Crohn's Disease (IBD)
Tinnitus
Atrial Fibrillation
Systematic Sclerosis

Download the tVNS® Patient App

Track, monitor and share your treatment

The innovative tVNS® Patient App is a wellness and session-diary application designed to help users keep a record of their well-being and the duration of their stimulation sessions.

The tVNS® Patient App is available now in the Google Play Store and in the Apple App Store (EU-only).

tVNS® Patient is fully compliant with the General Data Protection Regulation (GDPR), ensuring that patient data is handled with the utmost care and confidentiality.

Research and Patient App

Your tVNS® R device gives you access to two apps: the tVNS® Research and tVNS® Patient app.

All technical parameters can easily be reprogrammed and wirelessly transmitted with the tVNS® Research app, allowing the researcher to try completely new stimulation protocols. In addition, you can collect and store technical and patient data.

The tVNS® Patient app automatically stores all technical data (stimulation parameters, time and duration of the stimulation etc.) and offers a questionnaire for patient feedback.

tVNS® R for Research

Discover a Revolutionary Journey

with Innovative tVNS® Research Device

Meet the cutting-edge realm of vagus nerve stimulation research, where innovation meets precision in our state-of-the-art tVNS® R device. Crafted for flexibility and accuracy, it boasts complete wireless programmability, making it the perfect companion for in-depth clinical studies. Experience seamless control with the tVNS® Research and tVNS® Patient apps, integrating stimulation parameter adjustments, data collection, and patient feedback to elevate the depth and precision of your research.

Our commitment extends beyond technology; we're here to streamline your clinical trials, providing robust support for your studies, including a thorough CB safety report for swift ethics approvals and access to a global network of experts. Uncover the limitless potential of tVNS® R as it pioneers revolutionary paths in neurological research and transforms the landscape of patient care. Your journey to groundbreaking discoveries starts here.

How does tVNS® work?

You can use tVNS® anytime, anywhere. It's easy to use, portable, and discrete.

Treatment with tVNS® is characterized by its simplicity and adaptability to everyday life. At its core, tVNS® operates on the principle of neurostimulation, a process that engages the vagus nerve’s capacity to influence various bodily functions and systems. tVNS® stimulates the auricular branch of the vagus nerve (ABVN) through the skin with gentle and precise electrical impulses that propagate therapeutic signals to the brain, first to the brain stem and then to higher centers, aiming to correct dysregulation within the nervous system.

The application of tVNS® is designed with the patient in mind: it is easy, portable, and discreet, making it possible to incorporate treatment sessions into your schedule without interruption to your daily tasks. Whether you’re at home, in the office, or traveling, tVNS® provides a consistent and accessible means to manage symptoms of neurological disorders, including the reduction of seizure frequencies in epilepsy, among other conditions.

Each session with the tVNS® device is a step towards rebalancing the nervous system, leveraging the natural pathways of the body to foster healing and symptom relief. The device’s ease of use ensures that starting and maintaining a regimen with tVNS® is straightforward, empowering users to take control of their health in a non-intrusive, effective manner.

Epilepsy

After a 20 week treatment period, active tVNS® patients recorded an average 34.2% reduction of seizure frequency.

Prader-Willi-Syndrome

After a treatment period of 12 months, 80% of tVNS® patients recorded a reduction of mean number of outbursts per day of 50%, compared to mean number of outburst per day before treatment.

Migraines

Treatment with tVNS® led to a reduction of 50% of the frequency of days with migraines after a treatment period of 12 weeks.

Depression

tVNS® led to a reduction of depression-specific HAMD score of minimum 2-3 points in adult patients when used in parallel with psychopharmacological and psychotherapy treatments after a period of 9 weeks.

Non-Surgical Treatment

tVNS-L ® offers vagus treatment option in full patient control, which does not require surgery and does not involve invasive risks.

Remote Delivery

Minimal Side Effects

Device delivery, regular follow-up and any update on the therapy are possible remotely without leaving your home.

tVNS® has minimal side effects compared to drug treatments and invasive treatmens.

Innovative Technology

With the tVNS® Patient application, you can follow your treatment and share it with your doctor remotely.

More Flexibility

Pediatric Flexibility

Pacemaker, cerebral shunt, cardiovascular and respiratory diseases are not barriers to try tVNS therapy

Approved for children aged 3 and over, can be used from a doctor-approved newborn as there is no invasive intervention

Customized Therapy

tVNS ® is a personalized therapy that can be customized according to the patient's life routines and symptoms.

Easy to Use

More Controlled Life

tVNS® is easy to use, as small as a smartphone and perfectly suited for everyday life.

It can significantly reduce or eliminate symptoms. in this way can provide a more controlled life

The tVNS Health Services For Patients

We offer you a bundle of services including:

Device training
Access to doctors all over the world with transcutaneous vagus nerve stimulation experience
Therapy tracking to help an accurate usage of the device to help you get the maximum benefit

Support for Clinical Trials

We offer an individual adaptation of all parts for certain studies, e.g by changing the questionnaire in order to allow better feedback from the patient, or through the implementation of special stimulation parameters or technical ideas.

The tVNS® R device is defined as a device for investigational use. We can provide a CB report that proves the safety according to all medical device standards, in order to assist you with ethics approvals. So far, it has been accepted by all ethics committees.

In addition, we offer an international expert network and can direct any questions to experienced people around the world.

Triggered tVNS®

We offer a separate PC-based tVNS® manager software. This software enables reaction to outside trigger signals (e.g. ECG R-wave trigger generated by an external ECG system, transferred to a PC).

Thus, closed loop tVNS® or triggered tVNS® can be realized in a scientific setup.

Legacy and Hook Electrode

We offer two different types of electrode designs with our tVNS® devices:

The Hook Electrode (left) comes standard with all new tVNS® devices. It offers better fixation and usability during daily activities.

The Legacy Electrode (right) can be used if the patient has small ears or a special ear shape. The integrated slider allows for better adaption to the ear.

There are two types of electrodes, which are Legacy Electrode and Hook Electrode

Sham Stimulation

The well known sham stimulation at the ear lobe is still possible. Upon request, we support studies by providing other more sophisticated sham stimulation options.

PATIENT SERVICES AND SOLUTIONS WE OFFER

With a passion for solving unmet needs, we bring together technology, neuromodulation expertise and leading opinion leaders to create never-before-seen solutions.